Alzheimer’s Disease Fly Cell Atlas
AD-FCA: Whole organism single-nucleus RNA sequencing reveals systemic peripheral changes in Alzheimer’s Disease fly models
data portal – visualize, download, analysis
[AD-FCA link]
annotated data download:
head.h5ad, about 5GB [link]
body.h5ad, about 5GB [link]
raw files download:
Raw FASTQ files are available at NCBI/GEO (accession number GSE261656; caution! total size larger than 4TB).
publication:
Park YJ, Lu TC, Jackson T, Goodman LD, Ran L, Chen J, Liang CY, Harrison E, Ko C, Chen X, Wang B, Hsu AL, Ochoa E, Bieniek KF, Yamamoto S, Zhu Y, Zheng H, Qi Y, Bellen HJ, Li H. Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq. Neuron. 2025 Jul 9;113(13):2065-2082.e8. doi: 10.1016/j.neuron.2025.04.017. Epub 2025 May 16. PMID: 40381615; PMCID: PMC12245608.
contact: hongjie.li@bcm.edu
Hongjie Li Lab 